The average Trenbolone Acetate dose varies based on your cycle and stack. During an off-season bulking cycle, most bodybuilders find that 50mg every other day is comfortable and effective. Some men tolerate up to 100mg every other day with no issues, and they find that this does offers the best results for them. During a cutting cycle, people tend to push the envelope a little more with Tren and utilize doses even higher than 100mg every other day, but not everyone can tolerate these as the risk of side effects increases. No one should ever use more than 200mg every other day, even if they seem to tolerate it well.
Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts .  Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue-selectivity via means of modulation of the ER.   As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR),  and also as a "selective estrogen enzyme modulator" (SEEM).