The effect of subcutaneously administered clobetasol propionate on fertility and general reproductive toxicity was studied in rats at doses of 0, , 25, and 50 mcg/kg/day. Males were treated beginning 70 days before mating and females beginning 15 days before mating through day 7 of gestation. A dosage level of less than mcg/kg/day clobetasol propionate was considered to be the no-observed-effect-level (NOEL) for paternal and maternal general toxicity based on decreased weight gain and for male reproductive toxicity based on increased weights of the seminal vesicles. The female reproductive NOEL was mcg/kg/day (ratio of animal dose to proposed human dose of on a mg/m 2 /day basis) based on reduction in the numbers of estrous cycles during the pre-cohabitation period and an increase in the number of nonviable embryos at higher doses.
Advance Therapy provides hormone replacement therapy information, services and products including Testosterone, HCG and HGH. Medical Consultation, Age Management Physician Specialist, Testosterone Doctor, HGH Therapy Doctor, Anti-Aging and US Physician specialist referal is availble for adult hormone deficiency related symptoms. We also provide diet, exercise and fitness, lifestyle change, healthy aging, IV therapy, detoxification and nutritional program information. No information on this website is intended to cure any medical or health condition and is solely for informational and educational purpose.
Copyright Advance Therapy, LLC All Rights Reserved 2003-2017