Formulary status may vary and is subject to change. Please verify coverage and updated information on the website of your patient’s particular health plan or that of the Center for Medicare & Medicaid Services (CMS). Formulary coverage does not imply clinical efficacy or safety. GSK does not endorse individual plans. This information is not a guarantee of coverage or payment (partial or full). Actual benefits and out-of-pocket costs are determined by each plan administrator per its respective policies. Consumers are responsible for varying out-of-pocket costs based on the individual plan.
Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen , estrogen , or mineralocorticoid receptors , thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (. mast cell , eosinophil , neutrophil , macrophages , and lymphocytes ) and mediators (. histamine , eicosanoids , leukotrienes , and cytokines ) involved in inflammation . Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability .